1. As a family, these residues are known as sialic acids . 2. In bacterial systems, sialic acids are biosynthesized by an aldolase enzyme. 3. These enzymes can be used for chemoenzymatic synthesis of sialic acid derivatives. 4. Neural membranes have 20 times more sialic acid than other cellular membranes. 5. The most common form is tetrasialotransferrin, with four sialic acid chains. 6. Also, alpha-amylase contains a significant level of sialic acid . 7. ISSD is the most severe form of the sialic acid storage diseases. 8. Neuraminidases cleave the terminal sialic acid residues from carbohydrate chains in glycoproteins. 9. This suggests that sialic acid has an influence upon brain development and learning. 10. Cellular receptors for polyomaviruses are sialic acid residues of glycans, commonly gangliosides.
Mobile